Table 1.

Somatically Mutated Gene in Lung Neuroendocrine Tumors

Mutated Gene	Significance of the Molecular Alterations
MEN-1 47–49	Gene that products Menin, a protein that interacts with chromatin-associated protein complexes and also regulates some non-coding RNAs, participating in epigenetic control mechanisms
E3-Ub ligases47	Gene involved in Protein ubiquitination as posttranslational modification
ARID family47,49	Genes involved in the SWI–SNF complex and chromatin remodeling
KMT2 family47,48	Genes involved in covalent histone modification/chromatin remodeling
SMARCA447	Genes involved in chromatin remodeling
HNF1A47	Gene that regulated the expression of acute phase proteins and interleukin 1 receptor, which are involved with inflammation and might play a possible tumor suppressor role
FOXA347	Genes involved in covalent histone modification/chromatin remodeling
PSIP149	Genes involved in chromatin remodeling
PI3K/AKT/mTOR pathway48	Pathway involved in intracellular signaling pathway important in regulating the cell cycle