Table 2. Effects of randomized controlled trials and Mendelian randomization study in PTV on LDL-C and on ASCVD.
| Gene | RCT |
Mendelian randomization study in PTV |
|||
|---|---|---|---|---|---|
| Trial name | LDL cholesterol reduction (mg/dl) | ASCVD reduction (%) | LDL cholesterol reduction (mg/dl) | ASCVD reduction (%) | |
| APOB | NA | NA | NA | 43 | 72 |
| CETP | REVEAL | 26 | 9 | 12 | 30 |
| NPC1L1 | IMPROVE-IT | 17 | 6 | 12 | 53 |
| PCSK9 | FOURIER/ODYSSEY | 62/48 | 15/15 | 21 | 88 |
RCT, randomized controlled trial; PTV, protein truncating variant; ASCVD, atherosclerotic cardiovascular disease; APOB, apolipoprotein B; CETP, cholesteryl ester transfer protein; NPC1L1, Niemann-Pick C1-Like 1; PCSK9, proprotein convertase subtilisin-kexin type 9; NA, not available.