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. 2020 May 28;14(6):1060–1075. doi: 10.1016/j.stemcr.2020.04.011

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Tranylcypromine, Bromocriptine, and Flunarizine Reduce Spontaneous Apoptosis in PARK2 and PARK6 Neurons

(A) Images of day 39 neurons treated with 10 μM compounds for apoptosis analysis in static state. Scale bar, 100 μm.

(B) Quantitative data of the apoptosis analysis. Data represent the ratio of fluorescence intensity of cleaved caspase-3 in DMSO-treated control (WD39) neurons and that in 10 μM compound-treated neurons (n = 9 independent replicates; mean ± SEM). ^∗p < 0.05, ^∗∗p < 0.01 compared with DMSO; ¶p < 0.05 compared with DMSO-treated control (WD39) neuron by Wilcoxon signed rank test. n.s., not significant.