Table 1.
Summary of the Therapeutic Effect of Candidate Drugs in Various PD Models Used in This Study
| PARK2A |
PARK2B |
PARK6 |
Idiopathic PD |
Drosophila |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Apoptosis (Basal) | Apoptosis (+CCCP) | Mito phagy | Apoptosis (Basal) | Apoptosis (+CCCP) | Mito phagy | Apoptosis (Basal) | Apoptosis (+CCCP) | Mito phagy | Apoptosis (Basal) | Mito phagy | Move ment | ATP | Mitochondrial Reduction | |
| MRS 1220 | – | + | + | – | + | + | – | + | + | – | – | + | – | – |
| Tranylcypromine | – | – | + | + | + | – | + | – | + | – | + | – | – | NA |
| Flunarizine | – | + | + | + | + | + | + | – | + | + | + | – | – | NA |
| Bromocriptine | – | – | + | + | + | + | + | + | + | + | + | + | + | + |