Figure 3. H&E staining demonstrated microscopic finding metastatic lung and foci in lung that are represented with black asterisks and the number of metastatic microscopic nodules in the lung of mice (A-B). The area of lung metastasis indicated was evaluated by an image analyzer (Image J, NIH, USA) (C). ***P < 0.001 compared to control group and ^### P < 0.001 compared to 5-FU.