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Phylogenies of four different metastatic cases. Although there are large differences in tumor communities across the four metastasis sites, there exists common mechanisms, such as the early events of perturbed PI3K-Akt, ECM-receptor and focal adhesion pathways. (a) Breast cancer brain metastasis. (b) Breast cancer ovary metastasis. (c) Breast cancer bone metastasis. (d) Breast cancer GI metastasis
