Table 4.

The top 10 and bottom 10 chemical compounds identified by L1000 platform.

Name	CMap connectivity score	Description
Nimodipine	99.89	Calcium channel blocker
GW-501516	99.82	PPAR receptor agonist
Icilin	99.82	TRPV agonist
Fexofenadine	99.82	Histamine receptor antagonist
Modafinil	99.79	Adrenergic receptor agonist
Guanabenz	99.79	Alpha-2 selective adrenergic agonist
Mianserin	99.75	Serotonin receptor antagonist
CGP-53353	99.75	EGFR inhibitor
TUL-XXI039	99.72	Serine/threonine kinase inhibitor
Diphenoxylate	99.68	Opioid receptor agonist
Huperzine-a	-99.46	Acetylcholinesterase inhibitor
Perindopril	-99.47	ACE inhibitor
Solanine	-99.47	Acetylcholinesterase inhibitor
Phenothiazine	-99.51	Dopamine receptor antagonist
Tyrphostin-AG-1295	-99.68	PDGFR receptor inhibitor
Y-27152	-99.72	Potassium channel activator
Lenalidomide	-99.79	Antineoplastic
Androstenedione	-99.89	Cytochrome P450 inhibitor
Repaglinide	-99.89	Insulin secretagogue
Neurodazine	-99.89	Neurogenesis of nonpluripotent C2C12 myoblast inducer