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miR-138 is decreased in patients with psoriasis. This miRNA binds with 3′ UTR of RUNX3 to suppress its expression. Thus, down-regulation of miR-138 leads to up-regulation of RUNX3 which increases Th1/Th2 ratio [23]. miR-210 is increases in the psoriasis. This miRNA binds with 3′ UTR of FOXP3. FOXP3 is a master transcription factor for differentiation of Treg cells. Thus, miR-210 over-expression leads to reduction in the numbers of Treg cells [24].
