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. 2020 Jun 5;12(6):516. doi: 10.3390/pharmaceutics12060516

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Size, zeta potential, and encapsulation efficiency amongst the various ratios of miconazole:cholesterol:sodium oleate. (A) Size distribution and (B) zeta potential remained relatively similar, however high variation between vesicles eliminated consideration for 1:1:1 and 1:2:2 due to an inordinate number of vesicles stretching beyond the nano-range. (C) Encapsulation efficiency amongst the various ratios eliminated several formulations from consideration due to poor performance in relation to drug delivery, while two ratios conversely displayed exceptional loading potential. All data are presented as mean ± SE (n = 3).