Table 2.
Hormonal blood profile in adolescents with PCOS and “healthy” girls.
| Parameters | PCOS Group (n = 130) | Control Group (n = 30) | p-Level |
|---|---|---|---|
| LH **, IU/L | 9.0 (5.4–13.8) | 3.7 (2.5–4.7) | <0.0001 |
| FSH **, IU/L | 5.6 (4.4–6.9) | 5.3 (4.1–6.5) | 0.2856 |
| LH/FSH ** | 1.6 (1.0–2.3) | 0.7 (0.5–1.1) | <0.0001 |
| Testosterone **, nmol/L | 1.9 (1.2–2.5) | 0.8 (0.7–1.1) | <0.0001 |
| SHBG **, nmol/L | 37.0 (24.7–55.5) | 52.9 (39.0–67.6) | 0.0136 |
| FAI ** | 5.5 (2.8–7.0) | 1.6 (1.1–2.3) | <0.0001 |
| Cortisol *, nmol/L | 464.0 ± 147.6 | 284.0 ± 129.7 | <0.0001 |
| Prolactin **, mlU/L | 266.0 (175.0–405.0) | 189.0 (142.0–269.0) | 0.0141 |
| 17-OHP **, nmol/L | 4.1 (3.2–5.1) | 3.4 (2.7–3.8) | 0.0071 |
| DHEAS *, μmol/L | 6.8 ± 3.2 | 5.1 ± 1.5 | 0.0039 |
| DHEAS/FAI ** | 1,3 (0,9–2,1) | 3,2 (1,8–5,7) | <0,0001 |
| Androstenedione **, ng/mL | 15.8 (11.6–23.2) | 8.3 (6.5–10.8) | <0.0001 |
| АМH **, ng/mL | 9.5 (7.5–14.9) | 5.8 (3.8–6.9) | <0.0001 |
| Leptin *, ng/mL | 38.7 ± 27.1 | 23.7 ± 14.0 | 0.0178 |
* variable with a normal distribution, data are presented as mean ± standard deviation, Student’s t-test. ** variable with a non-normal distribution, data are presented as median (25–75 percentiles), Mann–Whitney U-test. LH: luteinizing hormone; TSH: thyroid-stimulating hormone; FSH: follicle-stimulating hormone; SHGB: sex hormone binding globulin; FAI: free androgen index; 17-OHP: 17α-OH progesterone; DHEAS: dehydroepiandrosterone sulfate; AMH: anti-Mullerian hormone.