Table 2.
The zone of inhibition (mm) of different antibiotics alone and in combination with AgNPs against ESBL producing bacteria by disc diffusion method.
| Antibiotics |
K. pneumoniae 700603 |
K. pneumoniae BK4 | E. coli SK30 | Enterobacter hormaechei NK15 | Over All Synergistic Effect |
|---|---|---|---|---|---|
| A. CAZ AgNPs B. CAZ + AgNPs Increase in fold area * |
8 11 10 0.56 |
11 11 14 0.61 |
8 12 10 0.56 |
6 13 11 2.36 |
1.0 |
| A. CIP (5 µg) AgNPs B. CIP + AgNPs Increase in fold area |
25 11 27 0.16 |
25 11 27 0.16 |
20 12 22 0.21 |
11 13 13 0.39 |
0.23 |
| A. CL AgNPs B. CL + AgNPs Increase in fold area |
16 11 16 0 |
12 11 15 0.56 |
12 12 16 0.77 |
12 13 15 0.56 |
0.47 |
| A. C (30 µg) AgNPs B. C + AgNPs Increase in fold area |
20 11 21 0.10 |
24 11 27 0.26 |
26 12 28 0.16 |
27 13 28 0.07 |
0.14 |
* Fold increases for different antibiotics were calculated by the formula (B2 − A2)/A2, where A and B are the zone of inhibition for only antibiotic and antibiotic with AgNPs, respectively. In case of no zone of inhibition, diameter of the disc (6 mm) was considered for the calculation.