AD	Alzheimer’s disease
Aβ	Amyloid-beta
APPswe/PS1dE9 mice	referred to as APP/PS1, double transgenic mouse model of Alzheimer’s disease over expressing amyloid precursor protein (APPswe), encoding the Swedish mutations at amino acids 595/596 and an exon-9-deleted human PS1 (PS1dE9)
TG-SwDI mice	triple transgenic mouse model of Alzheimer’s disease, express an AβPP with Aβ flanking, double Swedish mutations (Lys670→Asn/ Met671→Leu), the Dutch (Glu693→Gln), and the Iowa (Asp694→Asn) mutations (sequence numbering in the AβPP770 isoform notation)
TG2576 mice	transgenic mouse model, which express a 695-aa residue splice form of human amyloid precursor protein modified by the Swedish Familial AD double mutation K670N-M671L
TgCRND8 mice	transgenic mouse model of Alzheimer’s disease
GABA	gamma-aminobutyric acid
5XFAD mice	transgenic mice overexpress mutant human APP(695) with the Swedish (K670N, M671L), Florida (I716V), and London (V717I) Familial Alzheimer’s Disease (FAD) mutations along with human PS1 harboring two FAD mutations, M146L and L286V
APP	Amyloid Precursor Protein
PSEN1	presenilin 1
APOE	apolipoprotein E
MAPT	microtubule-associated protein tau
Trem2	triggering receptor expressed on myeloid cells 2
BACE1	Beta-Secretase 1
EGCG	Epigallocatechin-3-gallate
CTF	carboxyterminal fragments generated by α-secretase
sAPPα	generated when α-secretase cleaves APP
TNF-a	Tumor Necrosis Factor alpha
JNK	c-Jun N-terminal kinases
A11	oligomer-specific antibody
W20	oligomer-specific single chain variable fragment
TBS	tris-buffered saline
PBS	phosphate-buffered saline
DMSO	dimethyl sulfoxide
PCR	polymerase chain reaction
PMDs	protein misfolding disorders
LTP	long-term potentiation
LTD	long-term depression of excitatory synaptic transmission