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Timeline of milestone discoveries related to the three main genetic PD targets; a-synuclein, LRRK2 and GBA. DLB, Dementia with Lewy bodies; GBA, P-Glucocerebrosidase {Gcase) gene; LRRK2, Leucine—rich repeat kinase 2; PD, Parkinson’s disease; SNCA, α-synuclein gene; * Gaucher disease is a lysosomal storage disorder caused by biallelic GBA mutations.
