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Polymeric vaccine prototypes designed for the development of an intranasal vaccine against the Mycobacterium tuberculosis fusion protein ESAT-6/CFP-10 (ECH protein). In the oily core, Imiquimod, a TLR-7 agonist, was added as adjuvant to increase the immunogenicity of the fusion protein. Ag: Antigen, CS: Chitosan, INU: Inulin, pArg: Polyarginine, TLR-7: Toll-like receptor-7.
