ASD	artificial stomach-duodenum model
AUC	area under the curve
BCS	biopharmaceutics classification system
Cmax	maximal concentration
CO2	carbon dioxide
CYP	Cytochrome P450
DS	degree of supersaturation
EMA	European Medicines Agency
FaSSGF	fasted state simulated gastric fluids
FaSSIF-v1	fasted state simulated intestinal fluids version 1
GI	gastrointestinal
GIS	gastrointestinal simulator
GISDuodenum	duodenal chamber of the GIS
GISJejunum	jejunal chamber of the GIS
GISStomach	gastric chamber of the GIS
HPLC	high-performance liquid chromatography
HRM	high-resolution manometry
IR	immediate-release
ksec_d	secretion rate constant constant occuring in the duodenal chamber of the GIS
ksec_s	secretion rate constant constant occuring in the gastric chamber of the GIS
M&S	modeling and simulation
MTA	mass transport analysis
PBBM	physiologically-based biopharmaceutics modeling
PBPK	physiologically-based pharmacokinetics modeling
PDMA	Pharmaceuticals and Medical Devices Agency
PK	pharmacokinetics
PPI	proton-pump inhibitor
RLD	reference listed drug
t1/2,G	gastric half-life of emptying
TFA	trifluoroacetic acid
U.S. FDA	United States Food and Drug Administration
USP	United States Pharmacopoeia
Vd	volume in the duodenal chamber of the GIS
Vj	volume in the jejunal chamber of the GIS
Vs	volume in the gastric chamber of the GIS
Z_D	duodenal dissolution coefficient, considering the pH-dependent dissolution and solubility of loratadine
Z_J	jejunal dissolution coefficient, considering the pH-dependent dissolution and solubility of loratadine
Z_S	gastric dissolution coefficient, considering the pH-dependent dissolution and solubility of loratadine