Skip to main content
. 2020 Jun 18;12(6):566. doi: 10.3390/pharmaceutics12060566

Table 1.

Experimental conditions in each compartment for testing the different drug formulations of posaconazole in the GIS. The GISJejunum was initially empty and no secretions were simulated in this chamber.

Experimental Test Conditions GISStomach GISDuodenum GISJejunum
Dissolution Media Fasted state simulated gastric fluid (FaSSGF), pH 2 Fasted state simulated intestinal fluid version 1 (FaSSIF-v1), pH 6.5 /
Initial Volume 50 mL FaSSGF (pH 2) +

  • 250 mL of tap water (Conditions 1 and 2)

  • 250 mL of Coca-Cola® (Conditions 3 and 4)

 50 mL FaSSIF-v1 /
Secretions 1 mL/min of FaSSGF, pH 2 1 mL/min of FaSSIF-v1, pH 6.5 (4 x concentrated) /