Table 4.
Antimicrobial resistance genotype and phenotype observed in strain EC121.
| Antimicrobial Class | Genotype | Phenotype | |
|---|---|---|---|
| Antimicrobial Agent | MIC b (μg/mL) | ||
| Aminoglycosides | aph(3″)-Ib, aph(6)-Id, aph(4)-Ia, aac(3)-Iva | amikacin | 2 |
| gentamicin | 32 | ||
| β-lactams | blaTEM-1B, blaCTX-M-2 | ampicillin | ≥256 |
| piperacillin/tazobactam | >256/4 | ||
| ceftazidime | 64 | ||
| ceftriaxone | ≥512 | ||
| cefepime | 16 | ||
| ertapenem | ≤0.5 | ||
| imipenem | ≤0.5 | ||
| meropenem | ≤0.5 | ||
| aztreonam | >32 | ||
| Sulfonamides/Trimethoprim | sul2, sul1, sul1′, dfrA14, dfrA7 | trimethoprim/sulfamethoxazole | >128/2432 |
| Phenicols | catA1 | chloramphenicol | >64 |
| Tetracyclines | tet(A) | minocycline | 16 |
| tigecycline | 1 | ||
| Fluoroquinolones | parE(S458A); parC (S80I); gyrA (S83L and D87Y) | ciprofloxacin | >64 |
| Polymyxins | - | colistin | ≤0.25 |
| polymyxin B | ≤0.25 | ||
| Fosfomycin | - | fosfomycin | 0.25 |
| Macrolides | mph(A), mdf(A) | azithromycin | NT |
a chromosomal mutations and mobile genes related to antimicrobial resistance identified. b Resistance is highlighted in bold, following EUCAST (2019) breakpoints. NT—not tested.