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. 2020 Jun 2;9(6):1681. doi: 10.3390/jcm9061681

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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OPC proliferation and migration rates differ with age. (a) Proliferation rate of neonatal, postnatal and adult Oligodendrocyte Precursor Cells (OPCs). The number of proliferating OPCs also decreases with age. (b) Transmigrated cells of different ages after 20 h in control conditions: E16, P0, P15, and P60. The number of transmigrated cells decreases with age. (c) Histogram represents the migration speed at P0, P15, and P60. The migration speed is higher at P0, and it diminishes in OPCs from P15 and P60 mice. For all experimental groups, the results were analyzed using ANOVA and a Student´s t-test: * P < 0.05, ** P < 0.01, and *** P < 0.001.