Table 1.

Summary of compounds investigated in canine dermatological disorders. See the text for references.

Family of the Parental Compound	Compounds	Effect
Bioactive lipids	aliamides	Regulation of cutaneous inflammation and immunity
Polyunsaturated fatty acids	omega 3 fatty acids omega 6 fatty acids	Shifting of the arachidonic acid cascade towards production of less inflammatory mediators (prostaglandins and leukotrienes)
Botanical extracts	Rhemannia glutinosa Paeonia lactiflora Glycyrrhiza uralensis	Steroid sparing effect in addition to inflammatory, antioxidant, and antimicrobic properties
	Arctium lappa Althaea officinalis Malva sylvestris Ribes nigrum	Antioxidant and anti-inflammatory activities
	Ascophyllum nodosum Cucumis melo Haematococcus pluvialis Curcuma longa Camellia sinensis Punica granatum Polygonum cuspidatum Echinacea purpurea Grifola frondosa Glycine max	Reduction of IFNϒ and T lymphocytes, in addition to antioxidant and anti-inflammatory activities
	Lactobacillus rhamnosus Lactobacillus paracasei K71 Lactobacillus sakei Enterococcus spp.	Exact mechanism has yet to be fully elucidated; the supposed mechanism is modulation of the immune response toward a Th1 cell-mediated response
Vitamins and Minerals	vitamin A vitamin E vitamin D zinc	Prevention of nutritional deficiencies