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Nucleic acid helices complexed with (a) melittin and (b) LL-37. Peptide helices are shown in green (N to C polarity) or teal (C to N polarity), with dsDNA shown in red. (c) Induction of type 1 interferon production through TLR9-dependent mechanisms, highlighting the immunomodulatory capabilities of LL37-nucleic acid complexes. Image adapted from [213] under the Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/.
