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. 2020 Jun 14;7(2):56. doi: 10.3390/bioengineering7020056

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Action of DTX in the presence of GNPs. (a,b) The biocompatibility of GNPs was verified by measuring the cell survival fraction and DNA damage, respectively. (b,c) The action of the drug in the presence of GNPs was verified by measuring the DNA damage and cell survival fraction, respectively. (d) Mapping of DNA double strand breaks (DSBs) in control cells and cell treated with 50 nM DTX. DNA DSBs and nuclei are marked in green and blue, respectively. Scale bar is 20 µm. Error bars are standard deviations from 3 replicate measurements. * Represents a statistically significant difference (Welch’s unequal variance t-test, p < 0.05).