Table 3.
The biomarker concentrations with respect to clinical and pathological characteristics in breast cancer (BrC) subjects.
| Feature/Number of Patients (%) | YKL-40 Concentration (ng/mL) | TF Activity (pM) | Leptin Concentration (ng/mL) | hsAdiponectin Concentration (ng/mL) |
|---|---|---|---|---|
| Molecular subtypes | * | I vs. IV * | ||
| Luminal A | 1.91 | 13.92 | 12.61 | 28.88 |
| n = 50 (62%) | 1.33/2.92 | 10.61/25.20 | 5.57/20.64 | 22.62/33.63 |
| Luminal B HER2− | 2.81 | 36.18 | 12.38 | 25.24 |
| n = 13 (16%) | 1.83/2.85 | 19.62/39.18 | 4.00/19.21 | 20.51/27.71 |
| Luminal B HER2+ and Non-Luminal HER2+ n = 9 (11%) |
2.44 1.44/2.56 |
12.46 11.59/15.20 |
8.77 3.67/16.92 |
26.99 19.18/27.91 |
| Basal-like | 1.62 | 14.18 | 13.83 | 24.44 |
| n = 9 (11%) | 1.58/1.78 | 11.86/31.56 | 3.78/22.47 | 14.70/27.47 |
| Tumour diameter | ||||
| T1 (2 cm) | 1.87 | 14.99 | 12.38 | 27.13 |
| n = 55 (68%) | 1.42/2.92 | 11.62/25.88 | 4.43/22.47 | 20.64/32.31 |
| T2 (≥2 cm <5 cm) | 2.14 | 14.03 | 13.57 | 26.22 |
| n = 26 (32%) | 1.50/2.81 | 10.42/29.59 | 4.92/18.26 | 18.79/32.1 |
| Nodal status | ||||
| LN− | 2.16 | 16.29 | 12.30 | 27.02 |
| n = 62 (77%) | 1.52/2.92 | 11.17/25.88 | 4.7/22.47 | 20.51/32.13 |
| LN+ | 1.58 | 13.88 | 13.83 | 27.18 |
| n = 19 (23%) | 1.29/2.48 | 11.77/29.88 | 4.60/18.26 | 23.34/31.14 |
| Stage of disease | ||||
| IA | 2.19 | 18.28 | 12.30 | 27.06 |
| n = 40 (49%) | 1.48/3.04 | 11.53/25.72 | 4.85/26.21 | 20.36/31.95 |
| IIA + IIB | 1.89 | 13.88 | 12.63 | 27.05 |
| n = 41 (51%) | 1.36/2.51 | 11.62/29.59 | 4.70/17.89 | 23.34/32.10 |
| Elston and Ellis grade | ||||
| G1 + G2 | 2.03 | 14.06 | 12.51 | 26.83 |
| n = 65 (80%) | 1.43/2.92 | 11.47/25.88 | 4.92/20.64 | 20.64/32.13 |
| G3 | 1.63 | 15.10 | 14.35 | 27.59 |
| n = 16 (20%) | 1.39/2.43 | 12.31/37.58 | 4.57/20.37 | 17.61/29.70 |
| Histological type | * | * | ** | |
| Ductal | 2.03 | 14.99 | 13.53 | 26.23 |
| n = 69 (85%) | 1.58/2.90 | 11.47/28.76 | 5.34/22.47 | 19.76/30.30 |
| Lobular | 1.38 | 13.64 | 5.00 | 32.70 |
| n = 12 (15%) | 1.17/2.09 | 12.06/24.12 | 2.81/13.18 | 28.83/34.41 |
Abbreviations: LN—free of lymph node involvement, LN+—lymph node involvement, TF—tissue factor, hsAdiponectin—high sensitive adiponectin; significant p-values are highlighted: * <0.01; ** <0.001.