Figure 1.

Simplified scheme of the L-arginine/nitric oxide (NO) pathway. Pathway metabolites analyzed in the current study are written in bold script. Key pathway enzymes are written in grey italics. The inhibitory effect is marked in red dashed lines. PRMT: Arginine N-methyltransferase; CATs: Cationic amino acid transporters; DDAH: Dimethylarginine dimethylaminohydrolase; DMA: Dimethylamine; ADMA: Asymmetric dimethylarginine; SDMA: Symmetric dimethylarginine; NOS: Nitric oxide synthase; NO: Nitric oxide; ARG: Arginase; ASS: Argininosuccinate synthase; ASL: Argininosuccinate lyase.