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Association between dimethylamine (DMA) concentration and CRC advancement: (a) Overall tumor-node-metastasis (TNM) stage; (b) extent of primary tumor (T); (c) distant metastasis (M). Data presented as medians with an interquartile range and analyzed using the Kruskal-Wallis H test or Mann-Whitney U test (panel C). Statistically significant (p < 0.05) differences between CRC stages (0–4) are denoted by numbers above the dot-plots.
