Figure 5.

L-arginine/NO pathway metabolites as differential CRC biomarkers: (A) Arginine; (B) citrulline; (C) asymmetric dimethylarginine—ADMA; (D) symmetric dimethylarginine—SDMA; (E) dimethylamine—DMA; (F) metabolite panel consisting of SDMA, ADMA, and DMA. Data presented as receiver operating characteristic (ROC) curves with a 95% confidence interval (CI) and as an area under the ROC curve (AUC) with a 95% (CI) and significance of difference from AUC = 0.5, characteristic for a chance marker (represented as diagonal line). The red dot indicates Youden index.