Table 5.
Association between L-arginine/NO pathway metabolites and the sublocation of a primary tumor.
| Metabolite | Right-Side Colon | Left-Side Colon | Rectum | p-Value |
|---|---|---|---|---|
| Arg [µM] | 136.5 (111–168) 1 | 178.6 (146–219) 2,3 | 133.1 (117–152) 1 | 0.044 4 |
| Cit [µM] | 50.5 (44–57) | 50.2 (42–59) | 48.8 (44–54) | 0.915 5 |
| ADMA [µM] | 0.57 (0.49–0.68) | 0.65 (0.53–0.77) 3 | 0.57 (0.45–0.63) 1 | 0.034 6 |
| SDMA [µM] | 0.57 (0.5–0.77) | 0.62 (0.53–0.77) 3 | 0.54 (0.44–0.64) 1 | 0.031 6 |
| DMA [µM] | 52.2 (35–78) | 55.1 (35–74) | 66.2 (35–77) | 0.850 6 |
Data presented as medians with an interquartile range. Arg: Arginine; Cit: Citrulline; ADMA: Asymmetric dimethylarginine; SDMA: Symmetric dimethylarginine; DMA: Dimethylamine; 1 significantly different from left-sided cancers; 2 significantly different from right-sided cancers; 3 significantly different from rectal cancers; 4 data presented as geometric means with a 95% confidence interval and analyzed using one-way ANOVA on log-transformed data; 5 data presented as arithmetic means with a 95% confidence interval and analyzed using one-way ANOVA; 6 data presented as medians with an interquartile range and analyzed using the Kruskal-Wallis H test.