Table 7.
Characteristics of SDMA/citrulline/DMA panel as a CRC biomarker with reference to the primary tumor location.
| Parameter | Right-Side Colon | Left-Side Colon | Rectum |
|---|---|---|---|
| AUC (95% CI), p | 0.89 (0.81–0.95), p < 0.0001 | 0.91 (0.83–0.96), p < 0.0001 | 0.87 (0.79–0.92), p < 0.0001 |
| Criterion 1 | >0.264 | >0.47 | >0.413 |
| Sens. and spec. | 94.9 and 66.7 | 77.1 and 88.9 | 92.1 and 66.7 |
| Youden (J) index | 0.615 | 0.660 | 0.587 |
| LR+ and LR− | 2.9 and 0.08 | 6.9 and 0.26 | 2.8 and 0.12 |
CRC: Colorectal cancer; SDMA: Symmetric dimethylarginine; DMA: Dimethylamine; AUC: Area under the ROC curve; CI: Confidence interval; Sens.: Sensitivity; Spec.: Specificity; LR: Likelihood ratios; 1 predicted probabilities.