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. 2020 Jun 8;9(6):1782. doi: 10.3390/jcm9061782

Table 10.

Patient-related and surgery-related factors potentially affecting initial time-course in metabolite concentration following colorectal surgery.

Metabolite Parameter Patient-Related Factors Surgery-Related Factors
Age 1 Sex 2 [F vs. M] BMI 1 CCI 3 ASA 3 LoS 1 HLN 3 EBL 3
Arg Δ8/0 p = 0.552 0.72 vs. 0.98, p = 0.023 p = 0.263 p = 0.573 p = 0.880 p = 0.821 p = 0.258 ρ = 0.40, p = 0.002
Δ24/0 p = 0.842 p = 0.076 p = 0.513 p = 0.666 p = 0.756 p = 0.572 p = 0.791 p = 0.691
Δ24/8 p = 0.697 p = 0.677 p = 0.976 p = 0.525 p = 0.443 p = 0.743 p = 0.083 ρ = −0.59, p < 0.0001
Cit Δ8/0 p = 0.664 p = 0.182 p = 0.594 p = 0.559 p = 0.864 p = 0.996 p = 0.251 p = 0.630
Δ24/0 p = 0.486 p = 0.315 p = 0.483 p = 0.642 p = 0.887 p = 0.256 p = 0.387 p = 0.564
Δ24/8 p = 0.640 p = 0.408 p = 0.396 p = 0.529 p = 0.343 p = 0.147 p = 0.074 p = 0.414
ADMA Δ8/0 p = 0.695 p = 0.365 p = 0.776 p = 0.514 p = 0.541 p = 0.346 p = 0.610 ρ=0.28, p = 0.035
Δ24/0 p = 0.891 p = 0.312 p = 0.887 p = 0.414 p = 0.188 p = 0.933 p = 0.595 p = 0.738
Δ24/8 p = 0.858 p = 0.542 p = 0.552 p = 0.162 p = 0.599 p = 0.407 p = 0.566 ρ= −0.35, p = 0.008
SDMA Δ8/0 p = 0.728 p = 0.853 p = 0.815 p = 0.500 p = 0.261 p = 0.955 p = 0.895 p = 0.095
Δ24/0 p = 0.616 p = 0.096 p = 0.271 p = 0.704 p = 0.350 p = 0.170 p = 0.579 p = 0.630
Δ24/8 p = 0.421 p = 0.281 p = 0.369 p = 0.542 p = 0.938 p = 0.640 p = 0.870 p = 0.485
DMA Δ8/0 p = 0.994 p = 0.119 p = 0.531 p = 0.830 p = 0.923 p = 0.415 p = 0.943 p = 0.429
Δ24/0 p = 0.372 p = 0.114 p = 0.592 p = 0.654 p = 0.775 p = 0.240 p = 0.633 p = 0.860
Δ24/8 p = 0.073 p = 0.986 p = 0.735 p = 0.690 p = 0.943 p = 0.953 p = 0.613 ρ = −0.26, p = 0.052
Arg/ADMA Δ8/0 p = 0.859 p = 0.338 p = 0.178 p = 0.741 p = 0.518 p = 0.276 p = 0.115 ρ = 0.27, p = 0.041
Δ24/0 p = 0.921 0.85 vs. 1.04, p = 0.037 p = 0.343 p = 0.814 p = 0.986 p = 0.573 p = 0.819 p = 0.621
Δ24/8 p = 0.686 p = 0.367 p = 0.742 p = 0.781 p = 0.173 p = 0.259 p = 0.066 ρ = −0.51, p = 0.0001

1 Pearson correlation (r); 2 t-test for independent samples with data presented as means; 3 Spearman rank correlation (ρ); Arg: Arginine; Cit: Citrulline; ADMA: Asymmetric dimethylarginine; SDMA: Symmetric dimethylarginine; DMA: Dimethylamine; F vs. M: Females vs. males; BMI: Body mass index; CCI: The Charlson Comorbidity Index; ASA: The American Society of Anesthesiologists Physical Status Classification System; LoS: Length of surgery; HLN: Total of harvested lymph nodes (indicating extent of surgery); EBL: Estimated blood loss; Δ8/0 ratio between metabolite concentration at 8 h post incision and its preoperative level; Δ24/0 ratio between metabolite concentration at 24 h post incision and its preoperative level; Δ24/8 ratio between metabolite concentration at 24 and 8 h post incision.