Table 13.
Characteristics of L-arginine/NO pathway metabolites as predictors of postoperative ileus.
| Marker | Criterion | Sens. and Spec. | Youden (J) Index | LR+ and LR− |
|---|---|---|---|---|
| Arg-Δ24/0 | ≤0.805 | 85.7 and 47.2% | 0.329 | 1.6 and 0.3 |
| Arg-Δ72/24 | >1.66 | 57.9 and 67.7% | 0.255 | 1.8 and 0.62 |
| ADMA-Δ72/0 | >0.892 | 72.2 and 66.7% | 0.389 | 2.2 and 0.42 |
| ADMA-Δ72/24 | >1.10 | 73.7 and 71.4% | 0.451 | 2.6 and 0.37 |
| SDMA-Δ72/0 | >0.777 | 83.3 and 52.8% | 0.361 | 1.8 and 0.32 |
| SDMA-Δ72/8 | >0.826 | 84.2 and 52.9% | 0.372 | 1.8 and 0.3 |
| SDMA-Δ72/24 | >0.882 | 68.4 and 68.6% | 0.370 | 2.2 and 0.46 |
| Panel 1 | >0.409 2 | 72.2 and 84.9% | 0.571 | 4.8 and 0.3 |
| Arg/ADMA-Δ24/0 | ≤0.829 | 61.9 and 77.8% | 0.397 | 2.8 and 0.49 |
Sens.: Sensitivity; Spec.: Specificity; LR: Likelihood ratios; Arg: Arginine; ADMA: Asymmetric dimethylarginine; SDMA: Symmetric dimethylarginine; 1 a metabolite panel consisting of Arg-Δ24/0, ADMA-Δ72/0, and SDMA-Δ72/24—metabolite ratios selected in the logistic regression analysis as variables independently from others associated with a delayed restoration of bowel function (RoBF ≥ 5 days); 2 predicted probabilities.