Table 3.
Characteristics of the included studies evaluating serum klotho after living kidney donation.
| Study | Year | Country | N-Donor | Characteristics-Donor | Klotho before Donor Nephrectomy (pg/mL) | Other Markers before Donor Nephrectomy | Klotho after Donor Nephrectomy (pg/mL) | Other Markers after Donor Nephrectomy |
|---|---|---|---|---|---|---|---|---|
| Akimoto et al. | 2013 | Japan | 10 | Age 64 ± 9 years | 910 (755–1132) | eGFR | At day 5 | N/A |
| Male 4 (40%) | 87 (72–92) mL/min/1.73 m2 | 619 (544.6–688.5) | ||||||
| Living donor | ||||||||
| Ponte et al. | 2014 | Switzerland | 27 | Age 54 ± 11 years | 526 (482–615) | eGFR | At day 3 | At day 3 |
| FGF23 | ||||||||
| 26.9 (22.1–38.0) pg/mL | ||||||||
| At day 360 | ||||||||
| eGFR | ||||||||
| 95 ± 11 mL/min/1.73 m2 | 304 (266–491) | 63 ± 13 mL/min/1.73 m2 | ||||||
| Male 15 (57%) | FGF23 | At day 360 | FGF23 | |||||
| Living donor | 48.1 (37.4–60.0) pg/mL | 440 (398–613) | 45.2 (37.7–56.4) pg/mL | |||||
| Kimura et al. | 2015 | Japan | 15 | Age 59 ± 9 years | 1084 (795–1638) | eGFR | At day 5 | N/A |
| Male 8 (53%) | 74 ± 14 mL/min/1.73 m2 | 809 (638–1357) | ||||||
| Living donor | ||||||||
| Tan et al. | 2017 | Australia | 21 | Age 54.1 ± 14.7 | 564 (468–663) | eGFR | At 12 months | At 12 months |
| eGFR | ||||||||
| 94 (82–97) mL/min/1.73 m2 | 61 (49–69) ml/min/1.73 m2 | |||||||
| Male 13 (62%) | iFGF23 | 420 (378–555) | iFGF23 | |||||
| Living donor | 52 ± 15 pg/mL | 72 ± 22 pg/mL |
Abbreviations: eGFR, estimated glomerular filtration rate; FGF23, fibroblast growth factor-23; N/A, not available.