Table 4.
Characteristics of the included studies comparing serum klotho between living kidney donors and healthy volunteers.
| Study | Year | Country | N-Donor | Characteristics-Donor | Klotho-Donor (pg/mL) | Other Markers-Donor | N-Control | Klotho-Control (pg/mL) | Other Markers-Control |
|---|---|---|---|---|---|---|---|---|---|
| Thorsen et al. | 2016 | Norway | 35 | Age 56.5 ± 9.4 years | 669 (409–1161) | FGF23 | 35 healthy subjects | 725 (458–1222) | FGF23 |
| Male 21 (60%) | 62.6 (6.6–112) pg/mL | 51.8 (25.9–90) pg/mL | |||||||
| Living donor | |||||||||
| Time from donor nephrectomy | eGFR | eGFR | |||||||
| Median 15 years | 75.8 ± 12.3 mL/min/1.73 m2 | 99.0 ± 13.1 mL/min/1.73 m2 | |||||||
| Tan et al. | 2017 | Australia | 21 | Age 54.1 ± 14.7 years | 420 (378–555) | eGFR | 20 healthy subjects | 517 (434–667) | eGFR |
| Male 13 (62%) | 61 (49–69) mL/min/1.73 m2 | 97 (89–102) mL/min/1.73 m2 | |||||||
| Living donor | iFGF23 | iFGF | |||||||
| Time from donor nephrectomy 1 year | 72 ± 22 pg/mL | 52 ± 15 pg/mL |
Abbreviations: eGFR, estimated glomerular filtration rate; FGF23, fibroblast growth factor-23.