Table 6.

Water solubility of drugs used as inhibitors of SARS-CoV2 proteases.

Solubility Predictor	Famotidine	Ribavirin	Lopinvavir	Nafamostat
Log S (ESOL)	−1.25	−0.21	−6.64	−3.40
Solubility	5.60 × 10−2 M	6.19 × 10−1 M	2.31 × 10−7 M	4.00 × 10−4 M
Class	Very soluble	Very soluble	Poorly soluble	Soluble
Log S (Ali)	−3.88	−0.65	−8.21	−4.61
Solubility	1.32 × 10−4 M	2.24 × 10−1 M	6.10 × 10−9 M	2.46 × 10−5 M
Class	Soluble	Very soluble	Poorly soluble	Moderately soluble
Log S (SILICOS-IT)	−1.26	1.76	−10.05	−5.35
Solubility	5.43 × 10−2 M	5.73 × 101 M	8.85 × 10−11 M	4.46 × 10−6 M
Class	Soluble	Soluble	Insoluble	Moderately soluble

ESOL, Topological method implemented from Delaney [48]; Ali, Topological method implemented from Ali et al. [49]; SILICOS-IT, Fragmental method calculated FILTER-IT program.