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Biopharmaceutical parameters of E1P47, PLGA (E1P47) NPs and POPC (E1P47) LUVs release. Values express the mean and standard deviation of two independent assays.
| Formulation | Ka (h−1) | K10 (h−1) | Ltime (h) | Qmax (µg) | Tmax (h) |
|---|---|---|---|---|---|
| Free E1P47 | (1.9 ± 0.6) × 10−1 | (6.0 ± 4.9) × 10−2 | 1.4 ± 0.1 | 1.8 ± 0.4 | 11.1 ± 2.1 |
| PLGA (E1P47) NPs | (6.0 ± 0.8) × 10−1 | (2.8 ± 0.4) × 10−2 | 1.8 ± 1.5 | 8.0 ± 5.4 | 7.0 ± 3.4 |
| POPC (E1P47) LUVs | (1.1 ± 0.5) ×·10−1 | (1.4 ± 0.6) × 10−2 | 3.0 ± 2.5 | 1.5 ± 0.1 | 23.0 ± 1.7 |
