Table 4.
Values of the concentration of peptide extracted from the mucosa (Cp), weight of the mucosa (WP) and quantity of peptide retained in the ex vivo permeation study. Values express the mean and standard deviation of two independent assays.
| Formulation | Cp (µg/mL) | Wp (g) | Peptide Retained (Mean ± SD; µg/g × cm−2) | Concentration of Peptide Retained (µM) |
|---|---|---|---|---|
| Free E1P47 | 0.5 ± 0.4 | 0.4 ± 0.1 | 10.0 ± 7.0 | 3.0 ± 2.0 |
| PLGA (E1P47) NPs | 0.2 ± 0.1 | 0.4 ± 0.1 | 3.6 ± 0.1 | 1.0 ± 0.0 |
| POPC (E1P47) LUVs | 2.5 ± 0.2 | 0.4 ± 0.1 | 40.0 ± 8.0 | 11.0 ± 2.0 |