Figure 3.

Energy cofactor changes during SNMP vs. NMP. (a) ATP:ADP, (b) ATP:AMP, and (c) energy charge ratios were quantitatively much higher in the SNMP group after initiation of perfusion, but with large variance. Livers undergoing NMP demonstrate a consistent increase in energy cofactor, though absolute values were lower compared to SNMP indicating the more active metabolic state at physiologic temperatures. * indicates p < 0.05 for the random intercept mixed model. Abbreviations: ATP, adenosine triphosphate; ADP, adenosine diphosphate; AMP, adenosine monophosphate; SNMP, subnormothermic machine perfusion; NMP, normothermic machine perfusion.