Table 1.
Descriptive pharmacokinetic parameters of [99mTc]mebrofenin under each tested condition.
| Group | AUC0–30 min Blood ([cps/MBq].min) | AUC0–30 min Liver ([cps/MBq].min) | Xmax Liver (cps/MBq) | Tmax Live (min) | AUC0–30 min Intestine ([cps/MBq].min) |
|---|---|---|---|---|---|
|
Control (n = 5) |
51 ± 14 | 461 ± 109 | 26.5 ± 5.1 | 4.3 ± 1.7 | 424 ± 85 |
|
RIF (n = 5) |
109 ± 12 * | 385 ± 28 | 16.0 ± 0.9 * | 9.6 ± 0.8 * | 223 ± 54 * |
|
DTZ 10 mg/kg (n = 5) |
47 ± 4 | 520 ± 61 | 30.1 ± 3.2 | 4.3 ± 0.7 | 271 ± 30 * |
|
DTZ 20 mg/kg (n = 5) |
72 ± 23 | 562 ± 96 | 31.1 ± 5.8 | 5.4 ± 1.6 | 286 ± 102 * |
|
DTZ 40 mg/kg (n = 5) |
84 ± 30 * | 543 ± 95 | 24.3 ± 3.0 | 6.4 ± 0.8 | 238 ± 76 * |
|
CsA 0.01 mg/kg (n = 6) |
71 ± 9 | 660 ± 61 * | 34.6 ± 3.0 * | 4.0 ± 0.6 | 327 ± 61 |
|
CsA 0.1 mg/kg (n = 5) |
72 ± 11 | 601 ± 105 * | 27.9 ± 4.0 | 5.7 ± 1.9 | 223 ± 26 * |
|
CsA 0.5 mg/kg (n = 6) |
97 ± 9 * | 668 ± 48 * | 28.9 ± 2.1 | 7.6 ± 2.1 * | 239 ± 64 * |
|
CsA 1 mg/kg (n = 6) |
124 ± 9 * | 695 ± 40 * | 29.9 ± 2.5 | 7.4 ± 1.3 * | 275 ± 38 * |
|
CsA 5 mg/kg (n = 6) |
188 ± 18 * | 648 ± 66 * | 27.6 ± 2.1 | 9.1 ± 1.3 * | 314 ± 30 * |
Data are given as mean ± SD (n = 5 for control, RIF, DTZ 10 mg/kg, DTZ 20 mg/kg, DTZ 40 mg/kg, CsA 0.1 mg/kg groups and n = 6 for CsA 0.01 mg/kg, CsA 0.5 mg/kg, CsA 1 mg/kg, CsA 5 mg/kg groups). Asterisk (*) indicates significant differences (p < 0.05) in animals treated by rifampicin (RIF), diltiazem (DTZ) or cyclosporin A (CsA) compared with the control group (one-way ANOVA with a Bonferroni multiple-comparison test).