Table 2.

In vivo oral pharmacokinetic parameters when administered CFT-MIH-MNPs loaded formulation, oral control and intravenous control.

Pharmacokinetic Parameters	CFT Solution	CFT-MIH-MNPs Formulation
Dose (mg/kg)	50.0 ± 0.3	25.0 ± 0.3
Cmax (µg/mL)	2.0 ± 0.6	14.4 ± 1.8 ***
AUC0-24 (µg.h/mL)	16.1 ± 3.7	156.8 ± 0.3 ***
MRT (h)	8.4 ± 0.1	12.2 ± 0.2 ***
Tmax (h)	1.5	6
Clearance (L/h)	3.9 ± 0.4	1.6 ± 0.2 ***
Volume distribution (L)	33.0 ± 1.94	10.9 ± 2.4 **

^*** Extremely significant (p < 0.001), ^** highly significant (p < 0.01), ^* significant (p < 0.05), ^ns not significant (p > 0.05)