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. 2020 Jun 1;9(6):1669. doi: 10.3390/jcm9061669

Figure 7.

Figure 7

A 10-day long treatment with metformin does not affect the compromised general health (GH) status and motor dysfunction of RTT mice. RTT female mice received higher scores compared to WT mice in the GH evaluation (a), confirming the presence of phenotypic alterations. No treatment effects were found on this parameter. Total distance moved in the open field test (b) does not significantly differ among groups. RTT mice displayed shorter latencies to fall compared to WT controls in the dowel test (c). The metformin treatment did not affect the motor performance of the experimental subjects. N = 7–8. Data are mean ± SEM. Statistical significance was calculated by two-way ANOVA. WT: wild-type mice; RTT: MeCP2-308 heterozygous female mice; sal: saline; met: metformin; GH: general health.