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. 2020 Jun 1;9(6):1679. doi: 10.3390/jcm9061679

Figure 1.

Figure 1

HPT-axis and peripheral TH metabolism/signalling in mammals. (A) Hypothalamic-Pituitary-Thyroid (HPT)-axis and its regulatory feedback loops. (B) Mechanisms/enzymes and other proteins involved in the cell/tissue-specific TH metabolism and signalling. (C) Description of the species-specific pattern of the ensemble of proteins involved in TH metabolism and signalling in the ovary. The ovarian follicles are evidenced in the dashed rectangles. The zoom on a single follicle is reported in the upper dashed box in order to evidence the ensemble of the expressed proteins involved in peripheral TH metabolism and signalling. Abbreviations: TRH, thyrotropin releasing hormone; TSH, thyroid-stimulating hormone; T4, thyroxine; T3, triiodothyronine; T2, 3,5-diiodo-L-thyronine; rT3, reverse triiodothyronine; DIO1, DIO2, DIO3, deiodinases; MCT8–10, monocarboxylate transporter 8–10; OATP1C1, organic anion transporting polypeptide 1C1; αVβ3, integrin alpha (V) beta (3); TRα and TRβ, thyroid nuclear receptors isoform α, β; RXR, retinoic acid X receptor; ER, endoplasmic reticulum; Thra, thyroid hormone receptor alpha (Mouse); TRα1, TRα2, TRβ1 thyroid hormone receptors isoform α1, α2, β1 (Human).