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. 2020 Jun 3;10(6):854. doi: 10.3390/biom10060854

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Reaction mechanism of serine-β-lactamases (SBLs) and MBLs. General reaction mechanisms for cephalosporin hydrolysis by (a) SBLs and (b) MBLs. (c) Reaction intermediates formed during nitrocefin and imipenem hydrolysis by MBLs. The following abbreviations were employed: Enzyme (E), Substrate (S), Tetrahedral Intermediate (TI), Covalent Intermediate (CI), Product (P), Enzyme:Substrate Complex (ES), High-Energy Tetrahedral Intermediate (HE-TI), Anionic Intermediate (AI), and Enzyme:Product Complex (EP).