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Binding modes of substrate mimic inhibitors. (a) Modeled structure of meropenem bound to NDM-1; crystal complexes of (b) mercaptocarboxylate 1:IMP-1 (PDB 1dd6) [148], (c) L-CS319 L-6:NDM-1 (PDB 4u4l) [149], and (d) D-CS319 D-6:IMP-1 (PDB 5ev8) [150]. Hydrogen bonds and metal ligands interactions are drawn with dashed lines.
