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Binding modes of the product and intermediate mimic inhibitors. Crystal complexes of (a) NDM-1:meropenem hydrolysis product (PDB 4eyl) [69], (b) IMP-1:D-captopril (PDB 4c1g) [169], (c) a 3-aminophtalic acid inhibitor with IMP-1 (PDB 3wxc) [226], and (d) IMP-1:24 (PDB 1jjt) [173]. Hydrogen bonds and metal ligands interactions are drawn with dashed lines.
