Table 2.

Roles of MMP-7 in kidney diseases.

Disease	Role of MMP-7	Ref.
AKI 1	Protecting against AKI by priming tubular cells for proliferation and survival	[11]
UUO 2	Promoting renal fibrosis by activating partial EMT and β-catenin	[12]
Proteinuric CKD 3	Increasing urinary albumin excretion by impairing the glomerular filtration barrier	[7]
Diabetic nephropathy	Initiating diabetic nephropathy by expanding glomerular mesangium and thickening glomerular basement membrane	[79]
Chronic allograft nephropathy	MMPs, including MMP-7, contribute to the deregulation of extracellular matrix remodeling and possibly EMT.	[29]
Light chain deposition disease	The decrease of MMPs, including MMP-7, leads to the accumulation of tenascin and extracellular matrix	[30]
Amyloid light- chain amyloidosis	The increase of MMPs, including MMP-7, leads to the reduction of extracellular matrix	[30]
Renal cell carcinoma	Affecting tumor progression by regulating invasion and angiogenesis	[22]

¹ Acute kidney injury. ² Unilateral ureteral obstruction. ³ Chronic kidney disease.