Table 3. Trials that included pregnant subjects.
| Name | Location | Sponsor | Type | Pregnancy-specific design | ||
|---|---|---|---|---|---|---|
| A randomized controlled trial for honeysuckle decoction in the treatment of patients with novel COVID-19 infection | China | Nanjing Second Hospital (University) | Interventional | Prospective | RCT | No |
| An adaptive phase 2/3, randomized, double-blind, placebo-controlled, study assessing efficacy and safety of sarilumab for hospitalized patients with COVID-19 | France | Sanofi Aventis Research and Development (Industry) | Interventional | Prospective | RCT | No |
| Evaluation of the effect of high-dose vitamin C use in COVID-19 positive pregnants a | Turkey | n/a | Interventional | Prospective | Cohort | Yes |
| Effects of using mobile app on perceived stress during coronavirus (“COVID-19”) pandemic | United States | University of Arizona | Interventional | Prospective | RCT | Yes |
| Evaluation of blood results of COVID-19 positive pregnants a | Turkey | n/a | Observational | Prospective | Cohort | Yes |
| Maternal and neonatal outcomes from women infected with SARS-COV2 (COVID-19) during pregnancy | Australia | University of Melbourne | Observational | Prospective | Registry | Yes |
| Establishment of an early warning model for maternal and child vertical transmission of COVID-19 infection | China | Huazhong University of Science and Technology (University) | Observational | Retrospective | Case series | Yes |
| Study for the impact on fetus and neonates of vertical transmission of 2019-nCoV | China | Huazhong University of Science and Technology (University) | Observational | Retrospective | Case series | Yes |
| Retrospective analysis of anesthesia management of emergency cesarean section in nonpneumonia hospital of Wuhan during pandemic of novel coronavirus pneumonia (COVID-19) | China | Hubei Maternal and Child Health Care Hospital (University) | Observational | Retrospective | Case series | Yes |
| Cohort multiple randomized controlled trials open-label of immune modulatory drugs and other treatments in COVID-19 patients | France | Assistance publique – Hôpitaux de Paris (University) |
Observational | Prospective | Registry | No |
| COVID-19 biological samples collection | France | University Hospital, Bordeaux | Observational | Prospective | Case-only | No |
| Clinical characteristics of coronavirus disease 2019 (COVID-19) in pregnancy | Italy | University of Naples Federico II (University) |
Observational | Prospective | Registry | Yes |
| Clinical characteristics of coronavirus disease 2019 (COVID-19) in pregnancy: the Italian Registry on coronavirus in pregnancy | Italy | University of Naples Federico II (University) | Observational | Prospective | Registry | Yes |
| COVID-19 during pregnancy: a prospective Observational cohort | Netherlands | Máxima Medisch Centrum (University) | Observational | Prospective | Cohort | Yes |
| Outcomes of vascular surgery in COVID-19 infection: National Cohort Study | Spain | Vascular Investigation Network Spanish Society for Angiology and Vascular Surgery | Observational | Prospective | Registry | No |
| UKOSS: pandemic COVID-19 in pregnancy | United Kingdom | NIHR/University of Oxford (Government) | Observational | Prospective | Cohort | Yes |
| Outcomes of surgery in COVID-19 infection: international cohort study (CovidSurg) | United Kingdom | University of Birmingham | Observational | Prospective | Registry | No |
| Priority (pregnancy coronavirus outcomes registry) | United States | University of California | Observational | Prospective | Registry | Yes |
Abbreviations: COVID-19, coronavirus disease 2019; n/a, not applicable; NIHR, National Institute for Health Research; RCT, randomized controlled trial; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; UKOSS, UK Obstetric Surveillance System.
a
These two trials were registered on clinicaltrials.gov on April 7, 2020 but were later removed.