Table 3.
Hsp60 inhibitors
Types | Inhibitors | Mechanism and references |
---|---|---|
Natural Products | Mizoribine | To inhibit chaperone activity of the Hsp60-Hsp10 complex; to block ATP binding and hydrolysis33 |
Epolactaene | To inhibit chaperone activity of the Hsp60-Hsp10 complex683 | |
Myrtucommulone A (MC) | To inhibit chaperone activity of the Hsp60-Hsp10 complex686 | |
Stephacidin B | Undetermined694 | |
Avrainvillamide | Undetermined695 | |
Synthetic Compounds | O-carboranyl-phenoxyacetanilide | To inhibit chaperone activity of the Hsp60-Hsp10 complex; to block ATP binding and hydrolysis685 |
Gold porphyrins | To inhibit chaperone activity of the Hsp60-Hsp10 complex |