Figure 6.

Immunological assessment of the efficacy of the ABP dendrimer when administered topically to IMQ-induced psoriatic mice. Quantification of the infiltration of F4/80-positive cells (mainly macrophages) (A), T lymphocytes (B), and polynuclear neutrophils (C) in the skin of the back of each group of mice (n = 5 mice in the control group at a concentration of ABP = 0 mg/kg, n = 5 mice for the group at 5 mg/kg, and n = 6 mice for the group at 50 mg/kg) by immunohistochemistry; * p < 0.05, and ** p < 0.01 versus untreated mice (concentration of ABP = 0 mg/kg) using the one-way ANOVA test followed by the post hoc Dunnett’s test. Below each graph, representative immunochemistry pictures of the skin of the back of mice at day 7 from psoriatic control mouse, and mice treated daily with 5 mg/kg and 50 mg/kg of the ABP dendrimer, from top to bottom, respectively, are shown; black scale bars represent 50 µm.