Table 1.
Screening of solid and liquid lipids for Ciprofloxacin containing nanostructured lipid carriers (CIP-NLC) (Drug and lipids added in 1:10 ratio; 80 ± 2 °C; under continuous magnetic stirring at 2000 rpm for 10 mins).
| Solid/Liquid-Lipid | Lipid | Solubility |
|---|---|---|
| Solid | Precirol® ATO 5 | (+) |
| Compritol® 888 ATO | (−) | |
| DynasanTM 114 | (−) | |
| GeleolTM | (−) | |
| GelucireTM 43/01 | (−) | |
| DynasanTM 116 | (−) | |
| GelucireTM 50/13 | (−) | |
| GelucireTM 44/14 | (−) | |
| Softisan 154 | (−) | |
| Liquid | soybean oil | (−) |
| Captex® 355 EP | (−) | |
| castor oil | (−) | |
| sesame oil | (−) | |
| Maisine® CC | (−) | |
| Miglyol® 829 | (−) | |
| Oleic acid | (+) | |
| Capryol 90TM | (−) | |
| Olive oil | (−) |
(+): CIP is soluble in the melted lipid and does not precipitate on cooling; (−): CIP is either soluble in the molten lipid but precipitates on cooling or is insoluble in the lipid.