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Transcorneal flux and permeability of CIP from CIP-NLC, CIP-NLC-IG and CIP-C formulation through isolated rabbit cornea (Mean ± SD, n = 3).
| Formulation | Flux (µg/min/cm2) | Permeability (×10−5 cm/min) | Fold Enhancement with CIP-C | |
|---|---|---|---|---|
| Flux | p | |||
| CIP-C | 0.04 ± 0.01 | 2.3 ± 0.8 | - | - |
| CIP-NLC | 0.16 ± 0.01 # | 8.1 ± 0.4 # | 4 | 3.5 |
| CIP-NLC-IG2 | 0.09 ± 0.01 # | 4.4 ± 0.4 # | 2.2 | 1.9 |
# indicates statistically significant at p < 0.05 compared with CIP-C formulation.
