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. 2020 Jun 3;9(6):1719. doi: 10.3390/jcm9061719

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Brain regions showed overlap at the left amygdala when using both the VTA and PAG as seeds (red, PAG seed; green, VTA seed; yellow, overlapping region). (B) Scatter plots indicate the correlation between change in pain bothersomeness score and change in mean z value of VTA-left amygdala rsFC across all cLBP subjects adjusted for age and gender. (C) Scatter plots indicate the correlation between change in pain bothersomeness score and mean z values change in PAG-left amygdala rsFC across all cLBP subjects adjusted for age and gender. (D) Predicting the effects of acupuncture on pain in cLBP patients with the left amygdala cluster. Correlation between prediction value (rsFC value of PAG-amygdala at baseline) and pain bothersomeness score change across all cLBP patients adjusted for age and gender. Abbreviations: VTA, ventral tegmental area; PAG, periaqueductal gray; rsFC, resting-state functional connectivity; cLBP, chronic low back pain.