Table 2.
Significantly different brain regions identified after real and sham treatments in patients with chronic low back pain (cLBP), including age and gender as covariates.
| Seed | Contrast | Brain Regions | Cluster Size (Voxels) | MNI Coordinates (x, y, z) | Peak z-Value |
|---|---|---|---|---|---|
| VTA | Real > sham (post minus pre) | Bilateral ACC/mPFC * | 118 | −2, 28, −20 | 4.38 |
| Bilateral mPFC * | 51 | 2, 48, −12 | 4.09 | ||
| Left amygdala * | 19 | −24, −8, −18 | 3.25 | ||
| Sham > real (post minus pre) | Left SPL/AG | 119 | −22, −66, 62 | 4.84 | |
| Left precuneus/SPL | 156 | −8, −56, 64 | 3.71 | ||
| Left SPL/AG | 134 | −30, −50, 50 | 4.58 | ||
| Right anterior insula * | 39 | 38, 0, 6 | 3.49 | ||
| PAG | Real > sham (post minus pre) | RVM * | 83 | 6, −36, −48 | 3.82 |
| Right amygdala * | 33 | 20, −16, −14 | 3.72 | ||
| Left amygdala * | 28 | −24, −10, −18 | 3.72 | ||
| Sham > real (post minus pre) | Right precuneus/SPL | 190 | 14, −66, 40 | 4.19 | |
| Left insula * | 23 | −38, −14, 0 | 4.06 |
Notes: *, results were significant at cluster p < 0.05 after 3dFWHMx and 3dClustSim correction. Other results were significant at cluster p FDR < 0.05 corrected at the whole brain level. Abbreviations: VTA, ventral tegmental area; PAG, periaqueductal gray; ACC/mPFC, anterior cingulate cortex/medial frontal cortex; SPL/AG, superior parietal lobe/angular gyrus; RVM, rostroventromedial medulla.